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During passage through the intestinal wall and liver, the valine residue is cleaved by esterases, generating acyclovir. Famcyclovir is an antiherpetic prodrug with good bioavailability when given orally. It is used in genital herpes and herpes zoster. Cleavage of two acetate groups from the “false sugar” and oxidation of the purine ring to guanine yields penciclovir, the active form.
Dissolution test 42 The development of dissolution methods for ODTs is comparable to the approach taken for conventional tablets, and is practically identical. Dissolution conditions for drugs listed in a pharmacopoeia monograph, is a good place to start with scouting runs for a bioequivalent ODT. |
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