Drug Name Abilify

The therapeutic effect may result in part from a reaction with aldehydes, whereby polymerization of collagen molecules into fibrils is inhibited. Unwanted effects are: cutaneous damage (diminished resistance to mechanical stress with a tendency to form blisters), nephrotoxicity, bone marrow depression, and taste disturbances.
Zafirlukast is a long-acting, selective, and potent leukotriene receptor (LTD4, LTE4) antagonist with anti-inflammatory/ antiallergic activity and efficacy in the maintenance therapy of chronic asthma. It is given both orally and by inhalation. The onset of action is slow (3 to 14 d). Protective effects against inhaled LTD4 last up to 12 to 24 h.

 

The kinetic properties of the latter, however, necessitate adjustment of dosage in the course of treatment, because low dosage during the first days of treatment fails to provide pain relief, whereas high dosage of the drug, if continued, will lead to accumulation into a toxic concentration range (C).
Specific adverse reactions include irreversible pulmonary fibrosis due to busulfan and hemorrhagic cystitis caused by the cyclophosphamide metabolite acrolein (preventable by the uroprotectant mesna). Cisplatin binds to (but does not alkylate) DNA strands. Cystostatic antibiotics insert themselves into the DNA double strand; this may lead to strand breakage (e. g. , with bleomycin).